Where do giant cell tumors most commonly develop?

Giant cell tumors are typically found in proximity to joints, particularly at the metaphysis of long bones, which is the region where the shaft of the bone meets the end portion. They most frequently affect areas near the knee, such as the distal femur, proximal tibia, and sometimes the upper extremities near the elbow. This anatomical location is significant because these tumors can lead to joint pain, swelling, and may also impact joint functionality due to their proximity to the articular surface.

The other locations listed do not align with the common presentation of giant cell tumors. For instance, while some tumors may arise in the spine or involve the marrow cavity, giant cell tumors are distinct in their characteristic development near joints, leading to specific clinical presentations and treatment considerations.