Which age group is most commonly affected by giant cell tumors?

Giant cell tumors are most commonly found in young adults, particularly those between the ages of 20 and 40. This age range is significant because it corresponds to a phase in life where skeletal growth and change are prominent, and the tumors typically arise around the ends of long bones, often near the knee.

The reason young adults are particularly susceptible to giant cell tumors is related to the nature of bone growth and the hormonal changes that occur during this period. These tumors are generally considered benign but can be aggressive in their local behavior, leading to possible bone destruction if left untreated.

In contrast, children and older adults are less commonly diagnosed with giant cell tumors. In children, the usual skeletal development processes differ significantly, making them less likely to experience these types of tumors. Middle-aged adults and older adults can develop giant cell tumors, but the prevalence significantly decreases compared to young adults, with many cases diagnosed before the age of 40. This pattern underscores the association of giant cell tumors with younger populations.